Breaking the Fly Life Cycle: Largo® (Cyromazine 10 mg/g) as a Strategic Larvicide for Poultry Operations
Mobedco | Veterinary Technical Division
🧬 Introduction
Houseflies (Musca domestica) are more than a nuisance in poultry facilities—they are biological hazards, economic liabilities, and vectors of disease. They thrive in the nutrient-rich, moist conditions of poultry manure, reproducing rapidly and impacting animal health, welfare, and production efficiency.
At Mobedco, we offer an advanced larvicidal solution: Largo®, a granular product formulated with 10 mg of Cyromazine per gram, designed to specifically target fly larvae in manure and halt their development before they reach the adult, breeding stage.
🔍 Understanding the Fly Lifecycle for Targeted Control
Effective control depends on interrupting the fly lifecycle:
| Stage | Duration | Vulnerability |
|---|---|---|
| Egg | 8–16 hours | Hard to detect |
| Larva | 3 days – weeks | Optimal control point |
| Pupa | 2–10+ days | Resistant to most actives |
| Adult | 3–4 weeks | High mobility and reproduction |
Adulticides only treat the visible symptom (adult flies), but larvicides like Cyromazine target the cause—the manure-borne larvae that comprise up to 90% of the fly population during an outbreak.
⚗️ Mode of Action: How Cyromazine Works
Cyromazine is an insect growth regulator (IGR) that interferes with the molting process of fly larvae by disrupting chitin synthesis, which is critical for cuticle formation during development. Larvae exposed to Cyromazine:
Fail to pupate, thus never reach the adult stage.
Do not develop resistance quickly when used as part of a rotation program.
Do not harm beneficial insects like parasitic wasps when used appropriately.
Largo®’s concentration of 10 mg/g allows for precise dosage, ensuring that effective control is achieved without unnecessary chemical loading.
🧪 Field Application Guidelines for Largo®
Ideal Usage Sites:
Poultry manure belts
Deep litter systems
Pit floors and corners
Under cages and near leaking water lines
Recommended Dosage & Frequency:
| Season | Frequency | Notes |
|---|---|---|
| Peak Fly Season (Spring–Autumn) | Every 7–14 days | Especially in wet areas |
| Low Activity Season (Winter) | Every 3–4 weeks | Monitor with speck cards |
🌡️ Optimum activity: Apply when ambient temperature is 20–30°C with active larval presence.
🛠️ Integrated Fly Management (IFM) with Largo®
Largo® is most effective when deployed as part of a multi-pronged IFM program:
1. Sanitation & Manure Management
Dry manure to <50% moisture to reduce breeding potential.
Fix leaks, improve insulation, and use fans for ventilation.
Remove dead birds and spilled feed promptly.
2. Monitoring
Use fly speck cards (≥50 spots = treat; ≥100 = escalate).
Place sticky traps and visually inspect larvae in manure.
3. Biological Controls
Introduce predatory mites (Macrocheles spp.), parasitic wasps (Muscidifurax spp.).
Use Bacillus thuringiensis as a biological larvicide complement if available.
4. Chemical Rotation
Alternate Largo® with adulticides like permethrin or pyrethrin.
Avoid repeated use of a single class (e.g., organophosphates ((PHOXI-FAST 50)) to prevent resistance.
🧠 Technical Tip: Apply Largo® immediately after cleaning and re-stocking to preempt larval development in freshly laid manure.
📊 Benefits of Using Largo®
| Benefit | Impact |
|---|---|
| Larval targeting | Breaks the fly life cycle early |
| Prevents resistance build-up | Ideal for long-term farm management |
| No residues in eggs or meat | Safe for layer and broiler operations |
| Easy to apply granular form | Reduces labor and improves coverage |
| High concentration (10 mg/g Cyromazine) | Ensures effectiveness with small doses |
🛡️ Safety and Compliance
Withholding period: Zero days when used as recommended.
Compatibility: Safe for use around birds; does not interfere with parasitic wasps or beneficial microbes when applied correctly.
Sustainability: Supports antibiotic-free production by minimizing pathogen load from fly vectors.
Always use appropriate PPE (gloves, mask, eye protection) and follow national guidelines for chemical storage and application.
🧾 Sample Protocol: Deep Pit Layer House
Initial Application: Apply Largo® to manure zones 1–2 days post-cleaning.
Ongoing Treatment: Reapply every 10–14 days based on monitoring results.
Supplement: Use residual adulticide (e.g., Lambda-cyhalothrin) on vertical surfaces as needed.
Outbreak Response: In case of a spike (>100 specks/card), use fogged pyrethroids temporarily while maintaining Largo® larvicide treatment.
🐔 Conclusion: Largo® as a Core Component of Fly Management
With scientific backing, field-proven efficacy, and formulation precision, Largo® (Cyromazine 10 mg/g) is a cornerstone product for modern poultry fly management. It provides cost-effective, targeted, and residue-safe control—allowing poultry farms to stay clean, compliant, and productive.
📞 Contact Mobedco
For detailed application support or to order Largo®, connect with our technical team:
📧 info@mobedco.com | 🌐 www.mobedco.com | ☎ +962-6-5354949
Mobedco — Protecting Flocks with Precision.
