Protoban

• Protoban is composed of both Quinapyramine salts (Sulphate and Chloride) which differ in their absorption and action in animal body.
• The Sulphate salt is water soluble to which the curative action of Protoban could be attributed.
• The chloride salt which is less soluble forming a depot at the site of injection, it is absorbed slowly and the prophylactic action could be attributed.

Protoban is effective in prevention and treatment of trypanomisis in camels, cattle, horses, dogs, pigs, sheep and goats, caused by different Trypanosoma spp. (T. evansi, T. congolense, T. vivax, T. brucei, T. equinum, T. equiperdeum and T. simiae).

Camels, Cattle, Horses, Dogs, Pigs, Sheep and Goats.

• Add 15 ml water for injection to the 2.5 g injectable powder, shake to reconstitute the suspension.
• The recommended dose for Camels, Cattle, Dogs, Pigs, Sheep and Goats is 0.025 ml/kg body wight, subcutaneous route. Which is (Equivalent to Quinapyramine Sulphate: 2.5 mg/kg body wight and Quinapyramine Chloride 1.67 mg/kg body wight).
• In debilitated animals Protoban should be reconstituted to 30 ml and dose be divided up to 12 hourly installments.
• In areas where Nagana and Surra are endemic, herds should be given Protoban prophylactically every 2-3
• For horses it is advisable to dilute to 30 ml and be given intramuscularly into two or three injections at different sites.
• Protoban injection should be administered subcutaneously using sterile syringes and needles and employing an aseptic technique.
• Massage at the site of injection is good to disperse the drug and minimize the risk of local.

Meat: 21 days.

Milk: 4 days.

Upon correct assessment of body weight and dosing, side effects are less likely to occur, however, salivation, restlessness and tremors at the site of injection had been observed in some susceptible animals.

These signs are only transitory and need resting of the animal in a quiet place.

• Toxicity is not so important, except in young animals where over dosage may cause sweating, salivation, trembling and followed in severe cases by an increase in heart rate and respiration, collapse and possibly death.
• In cattle some time rusty colored diarrhea might be observed.
• The chloride salt is absorbed very much more slowly than the sulphate and used by itself is nontoxic.

Store in a dark place at a temperature below 30℃.