Sodium Bicarbonate 8.4%
Antacid Emergency Therapy Injectable Solution contains 8.4% Sodium Bicarbonate.
Description
Each 1 ml contains:
Sodium Bicarbonate 84 mg
Sodium Bicarbonate is indicated in the treatment of metabolic acidosis which may be due to
severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe
dehydration, cardiac arrest and severe primary lactic acidosis.
Sodium Bicarbonate is also indicated in severe diarrhea which is often accompanied by a
significant loss of bicarbonate. Sodium Bicarbonate 8.4% is indicated in the treatment of
metabolic acidosis in cattle, horse, sheep and dogs depending upon causative factor.
Cattle, Horses, Sheep and Dogs.
Sodium Bicarbonate 8.4% is injected intravenously.
Sodium Bicarbonate 8.4% solution is often added to other intravenous fluids for the less
urgent forms of metabolic acidosis. The amount of bicarbonate to be given over a 4 to 8 hour
period is approximately 2 to 5 mEq/kg of bodyweight (2-5.5 ml/kg bodyweight) depending
upon the severity of the acidosis as judged by the lowering of total CO2 content, blood pH
and clinical condition of the animal.
Bicarbonate therapy should always be planned in stepwise fashion since the degree of
response from a given dose is not precisely predictable. Initially, an infusion of 2 to 5 mEq /
kg of body weight over a period of 4 to 8 hours will produce a measurable improvement in the
abnormal acid-base status of the blood. Completion of therapy is dependent upon the clinical
response of the animal. If severe symptoms have abated, then frequency of administration and
size of the dose should be reduced.
Sodium Bicarbonate is contraindicated in animals losing chloride by vomiting and in animals
receiving diuretics known to produce a hypochloremic alkalosis
Caution should be taken in emergencies where very rapid infusion of large quantities of
bicarbonate is indicated, such as cardiac arrest.
Sodium Bicarbonate solutions are hypertonic and may produce an undesirable rise in plasma
sodium concentration during the process of correction of metabolic acidosis. During cardiac
arrest, however, the risks from acidosis exceed those of hypernatremia. In cattle and horses,
200 to 300 mL of 8.4% solution may be given undiluted by rapid infusion using a needle and
syringe.
Bicarbonate therapy is directed at producing a substantial correction of low total CO2 content
and blood pH, but risks of overdosage and alkalosis should be avoided. Repeated fractional
doses and periodic monitoring by appropriate laboratory tests are therefore recommended to
minimize the possibility of overdosage.
Sodium Bicarbonate addition to parenteral solutions containing calcium should be avoided
except where compatibility has been previously established.
Precipitation or haze may result from sodium bicarbonate-calcium admixtures, and the
resulting solution should not be administered
Nill
Store at a temperature below 30 ◦C.
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